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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Common disease-common variant ： ウィキペディア英語版 Common disease-common variant The common disease-common variant (often abbreviated CD-CV) hypothesis predicts that common disease-causing alleles, or variants, will be found in all human populations which manifest a given disease. Common variants (not necessarily disease-causing) are known to exist in coding and regulatory sequences of genes. According to the CD-CV hypothesis, some of those variants lead to susceptibility to complex polygenic diseases. Each variant at each gene influencing a complex disease will have a small additive or multiplicative effect on the disease phenotype. These diseases, or traits, are evolutionary neutral in part because so many genes influence the traits. The hypothesis has held true in the case of putative causal variants in apolipoprotein E, including ''APOE'' ε4, associated with Alzheimer's disease.〔Expanded high-resolution genetic study of 109 Swedish families with Alzheimer's disease, Anna Sillén, Jorge Andrade, Lena Lilius, Charlotte Forsell, Karin Axelman, Jacob Odeberg, Bengt Winblad and Caroline Graff, European Journal of Human Genetics (2008) 16, 202–208; ; published online 24 October 2007〕 IL23R has been found to be associated with Crohn's disease; the at-risk allele has a frequency 93% in the general population . One common form of variation across human genomes is called a single nucleotide polymorphism (SNP). As indicated by the name, SNPs are single base changes in the DNA. SNP variants tend to be common in different human populations. These polymorphisms have been valuable as genomic signposts, or "markers," in the search for common variants that influence susceptibility to common diseases. Recently published research has linked common SNPs to diseases such as type 2 diabetes, Alzheimer's, schizophrenia and hypertension. ==See also== *Rare functional variant 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Common disease-common variant」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.